Let’s just rewrite this story

Hundreds of children with cancer being denied potentially lifesaving drugs

Where the Hell’s Mengele when you need him? For we’ve got to start doing medical experiments on sick kids.

That being what the actual problem is. We don’t test drugs on kids. Therefore they either not approved or we’re not sure they will work on kids. Thus they don’t get them.

The solution is to test drugs on kids.

6 comments on “Let’s just rewrite this story

  1. If you develop a drug for adults you are obliged to trial the same indications in children, unless you can persuade EMA’s most uncompromising committee that it isn’t possible. In one case I know well they ordered a paediatric trial for a product developed for colorectal cancer, which probably occurs in a single digit number of kids per year.

    So imagine my surprise when looking at the data underlying this story, and all the cases are of cancers so rare that they get very little pharma research attention in adults, let aalone kids.

    I guess we could make targeted therapies for some of them but they would be so expensive we’d be accused of profiteering by denying kids affordable drugs again.

  2. Thalidomide is approved for cancer treatment. They will have tried that.
    There are probably dozens of approved drugs which, repurposed, would have beneficial effects. (Poster child for this: viagra.) But big pharma, test protocols and patent rules are not set up to help.

  3. I’m sure BiG will put me straight if I’ve got the wrong end of the stick ….

    AIUI testing on children is made more difficult and dangerous because the dosage for most drugs doesn’t scale linearly. A drug dose of X that works and is safe on a, say, 80 kg man doesn’t mean that a dose of X/4 will work and be safe on a 20 kg child.

    As an aside, I’m sure I heard something about some drugs where the same dose on men and women, even of the same weight, can have different effects and be more dangerous for women. (I meant to raise this in a previous thread),

  4. @BiG

    Imagine my surprise when looking at the data underlying this story, and all the cases are of cancers so rare that they get very little pharma research attention in adults, let alone kids.

    Thanks

    .
    @BiND

    Dose not weight correlated – yes

    1980s Young teen – Migraine: I was prescribed Ponstan – relieved pain a bit, nothing else. Our pub manager (2.5x my weight) prescribed same dose for something – knocked him out.

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