I\’ve no idea whether it\’s a good theory of cancer but it\’s certainly an interesting one:
Together we developed the theory that cancer tumours are a type of atavism that appears in the adult form when something disrupts the silencing of ancestral genes. The reason that cancer deploys so many formidable survival traits in succession, is, we think, because the ancient genetic toolkit active in the earliest stages of embryogenesis gets switched back on, re-activating the Proterozoic developmental plan for building cell colonies. If you travelled in a time machine back one billion years, you would see many clumps of cells resembling modern cancer tumours.
The implications of our theory, if correct, are profound. Rather than cancers being rogue cells degenerating randomly into genetic chaos, they are better regarded as organised footsoldiers marching to the beat of an ancient drum, recapitulating a billion-year-old lifestyle. As cancer progresses in the body, so more and more of the ancestral core within the genetic toolkit is activated, replaying evolution\’s story in reverse sequence. And each step confers a more malignant trait, making the oncologist\’s job harder.
Do we have any doctorly types here who could give us a view?