He has a particular distaste for the trans rights movement. In a 2017 JRE episode with Shapiro, he describes his radicalization on the issue as stemming from anger at Fallon Fox, a trans woman who competed in women’s MMA fights:
I didn’t have a dog in this fight. I was completely open and liberal about it — until there was a case where a man who had been a man for 30 years became a woman for a little less than two years and then started MMA fighting women. Beating the fuck out of these women, and then not proclaiming that he or she used to be a man … if you ever watch the fights, she wasn’t winning because she was skillful. She was fucking manhandling these women, it was ugly.
This very short paragraph contains all the classic tropes of transphobia: a denial of the authenticity of trans people’s identity, an insinuation that they’re a threat to cis folks, and a claim that they’re using their gender identity to somehow get ahead in life. It is, to quote Rogan, ugly, and one of many such examples when it comes to trans issues.
Someone physically male fighting people physically female, yes, that sounds like something to worry about.
Well, except to the toothsuckers at Vox perhaps.