But a way for me to think about this:
The vaccine is an individualised neoantigen therapy. It is designed to trigger the immune system so it can fight back against a patient’s specific type of cancer and tumour.
Known as mRNA-4157 (V940), the vaccine targets tumour neoantigens, which are expressed by tumours in a particular patient. These are markers on the tumour that can potentially be recognised by the immune system.
The jab carries coding for up to 34 neoantigens and activates an anti-tumour immune response based on the unique mutations in a patient’s cancer.
To personalise it, a sample of tumour is removed during the patient’s surgery, followed by DNA sequencing and the use of artificial intelligence. The result is a custom-built anti-cancer jab that is specific to the patient’s tumour.
There’s a story doing the rounds about what happened to a covid patient. Flus and the like can kill through a “cytokine storm”. When the immune system goes absolutely wild trying to kill off whatever and it kills the whole body.
However, occasionally – occasionally! – such a storm doesn;t kill the patient. And this happened to that one covid patient – his terminal cancer got killed off by the storm and he didn’t. The storm was, that is, just enough to kill everything that wasn’t exactly him but not enough to kill him.
So, me being me, I’ve been just assuming that a decent treatment for all sorts of things would be an induced cytokine storm (not that I actually know what one is in any detail) that did that 99% but not the last 1%.
And it’s possible to think of this new vaccine – possible, obviously, because that’s the way I am thinking of it, rightly or wrongly – as being a smaller version of just that. Get the immune system to go wild on the cancer. Sorta, go Israeli on Gaza rather than go British on Dresden as in the true storm.
It’s not right but suits me as a mental model.
The problem with such not right metnal models is that this then leads one on to further speculation. What about inducing more vicious but not fatally vicious such storms? How far could you take this over-excite the immune system?